Erythritol, Erythronate, and Cardiovascular Outcomes in Older Adults in the ARIC Study
Authors' conclusion
Circulating erythritol and erythronate levels are markers of cardiometabolic health and cardiovascular outcomes in an older adult population. In particular, erythronate is associated with all cardiovascular outcomes assessed. Future studies should assess the role of erythronate and its related pathways in cardiovascular disease.
Study context
- Population
- Older adults in the ARIC (Atherosclerosis Risk In Communities) study (visit 5, 2011–2013) without prevalent cardiovascular disease and with metabolomic profilingparticipants without prevalent cardiovascular disease and with metabolomic profiling
- Participants
- 4,006 adults
- Comparison
- Associations of log-transformed erythritol and erythronate with cardiovascular risk factors and events
- Outcome
- Baseline characteristics by highest tertiles of erythritol or erythronate
Methodological detailsmetabolomic profiling, mass spectrometry
- Metabolomic profiling
- Mass spectrometry
Main finding
As reported in the abstract
Older, more likely to have diabetes, hypertension, hyperlipidemia, or microalbuminuria, higher body mass index and cardiac biomarkers and lower estimated glomerular filtration rate
P < 0.001
Further findings
Coronary heart disease (erythronate)
| Comparison | HR (95% CI) | P value | |
|---|---|---|---|
| Erythronate | 1.30 (1.04–1.61) | P = 0.02 | |
| 0.512Hazard ratio (log scale) |
Stroke (erythronate)
| Comparison | HR (95% CI) | P value | |
|---|---|---|---|
| Erythronate | 1.40 (1.08–1.83) | P = 0.012 | |
| 0.512Hazard ratio (log scale) |
Heart failure (HF) with reduced ejection fraction (erythronate)
| Comparison | HR (95% CI) | P value | |
|---|---|---|---|
| Erythronate | 1.38 (1.09–1.74) | P = 0.007 | |
| 0.512Hazard ratio (log scale) |
HF hospitalization, HF with preserved ejection fraction, cardiovascular death, and total mortality · median follow-up of 8.41 (7.62, 8.93) years
- Higher erythritol and erythronate concentrations significantly associated
- After adjustment for demographics and traditional cardiovascular risk factors
Effect modification by diabetes status
- Diabetes status did not modify any of these associations
- P for interaction > 0.20
Original publication
Summarised from the published abstract; every number is checked against it