Does Adiponectin Inform Cardiovascular Risk in Older Adults??: The ARIC Study
Main finding · Incident HFResult — go to the resultHazard ratio 1.91 per natural-log unit increase 95% CI 1.49–2.44Authors' conclusion
Elevated adiponectin and NT-proBNP in older adults are associated with increased risk for HF and CVD death beyond traditional risk factors.
Study context
- Population
- Atherosclerosis Risk in Communities participants without baseline cardiovascular disease (CVD) at visit 5, mean age 75participants without baseline CVD at visit 5
- Participants
- 4,729 participants
- Exposure
- Adiponectin and adiponectin/NT-proBNP category associations with incident CVD events
- Outcome
- Incident HF
- Follow-up
- Median 5.5 years
Main finding
As reported in the abstract
Hazard ratio
1.91 per natural-log unit increase
95% CI 1.49–2.44
Higher adiponectin
HR 1.91 per natural-log unit increase (95% CI 1.49–2.44)
Per natural-log unit increase, as printed
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| CVD death · median follow-up of 5.5 years | HR 1.67 per natural-log unit increase (95% CI 1.19–2.32) | |
| HF and CVD death by adiponectin/NT-proBNP categoryA+/N+ vs A+/N- · HF | HR 5.41 (95% CI 2.72–10.78) | |
| HF and CVD death by adiponectin/NT-proBNP categoryA+/N+ vs A+/N- · CVD death | HR 3.50 (95% CI 1.48–8.24) | |
| HF and CVD death by adiponectin/NT-proBNP categoryA-/N+ vs A+/N- · HF | HR 2.84 (95% CI 1.41–5.72) | |
| 0.050.21520Hazard ratio (log scale) |
Heart failure with preserved ejection fraction
- No significant association between adiponectin and heart failure with preserved ejection fraction after adjusting for NT-proBNP
HF and CVD death by adiponectin/NT-proBNP category
- A-/N- had no increased event risk
Metabolomic signature of A+/N+
- Similar to NT-proBNP's
- 88%
- Acylcarnitine species consistent with incomplete beta-oxidation; top-associated metabolites were significantly associated with HF and CVD death
Original publication
Does Adiponectin Inform Cardiovascular Risk in Older Adults??: The ARIC Study. JACC Adv. Published 20 February 2025. doi:10.
Summarised from the published abstract; every number is checked against it