Modest Effects of Intensive Blood Pressure–Lowering on Quality of Life in Patients at High Cardiovascular Risk: The ESPRIT Trial
Primary result · EQ-5D visual analog scale score changeResult — go to the resultMean difference 1.26 95% CI 0.55–1.98Authors' conclusion
Intensive BP treatment, targeting office SBP to <120 mm Hg, produced modest benefits to HRQoL among hypertensive patients with high cardiovascular risk.
Study context
- Population
- Hypertensive patients with high CV risk
- Participants
- 5,398 vs 5,406
- Comparison
- Intensive vs standard blood pressure (BP)-lowering treatment
- Intensive treatmentn = 5,398
- Standard treatmentn = 5,406reference
- Primary endpoint
- Change in health-related quality of life (HRQoL) (EQ-5D-5L) from baseline to final follow-up visit
- Follow-up
- 3.4 years
Methodological detailsopen-label, blinded-outcome
- Open-label
- Blinded-outcome
Primary result
EQ-5D visual analog scale score change · 3.4 years
Mean difference
1.26
95% CI 0.55–1.98
P < 0.001
Change by group
Intensive treatment
0.56
increase · point
Standard treatment
0.50
decrease · point
Intensive treatmentvs Standard treatment
mean difference 1.26 (95% CI 0.55–1.98); P < 0.001
As reported in the abstract
Further findings
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| Meaningful improvementvs worsening in EQ-5D visual analog scale | 1.16 (1.04–1.30) | P = 0.007 | |
| 0.512Relative risk (log scale) |
Categorical changes in 5 EQ-5D domains · baseline to final follow-up visit
- No statistical differences between the 2 groups
Original publication
Modest Effects of Intensive Blood Pressure–Lowering on Quality of Life in Patients at High Cardiovascular Risk: The ESPRIT Trial. J Am Coll Cardiol. Published 17 October 2025. doi:10.
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