Estimated Glomerular Filtration Rate Variability and Incident Heart Failure in Adults With Type 2 Diabetes
Authors' conclusion
Higher variability in eGFR is independently associated with an increased risk of incident HF in adults with type 2 diabetes.
Study context
- Population
- Adults with type 2 diabetes in the ACCORD (Action to Control Cardiovascular Risk in Diabetes) study with ≥5 estimated glomerular filtration rate (eGFR) measurements in the first 24 months193 developed heart failure (HF) over a median follow-up of 3 years
- Participants
- 7,601 adults
- Comparison
- eGFR variability and incident HF
- Outcome
- Incident HF across quartiles of eGFR variability
- Follow-up
- Median 3 years
Main finding
As reported in the abstract
- HF incidence increased across quartiles of eGFR variability
Further findings
| Outcome | Estimate | P value | |
|---|---|---|---|
| Incident HF, highestvs lowest quartile of eGFR CVFully adjusted models | HR 1.88 (95% CI 1.09–3.22) | P for trend = 0.019 | |
| Incident HF per 1-SD increment in eGFR variability metricsCV | HR 1.15 per 1-SD increment (95% CI 0.99–1.33) | ||
| Incident HF per 1-SD increment in eGFR variability metricsSD | HR 1.16 per 1-SD increment (95% CI 1.01–1.33) | ||
| Incident HF per 1-SD increment in eGFR variability metricsVariability independent of the mean | HR 1.18 per 1-SD increment (95% CI 1.03–1.35) | ||
| 0.20.5125Hazard ratio (log scale) |
Participant characteristics
- Mean age
- 63 ± 6.5 years
- Women
- 39.1%
- White
- 63%
Original publication
Estimated Glomerular Filtration Rate Variability and Incident Heart Failure in Adults With Type 2 Diabetes. JACC Adv. Published 10 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →