Heart failure & cardiomyopathies
Estimated left ventricular end diastolic pressure by mean left atrial transit time predicts adverse clinical outcome risk
Authors' conclusion
Predicted LVEDP by LATT corroborated well with invasive LVEDP and biomarkers that are linked to increased LVEDP and was associated with a significant long-term risk of adverse clinical outcomes.
Study context
- Population
- Subjects assessed by CMR for mean left atrial transit time, including normal controlssubjects prospectively enrolled, including 15 normal controls, 548 patients divided into Predicted LVEDP (pLVEDP) subgroups, invasive left ventricular end diastolic pressure (LVEDP) subgroup of 46 patients · normal controls 15 · patients divided by pLVEDP 548 · subgroup with invasive LVEDP 46
- Participants
- 563 subjects
- Exposure
- Elevated pLVEDP vs pLVEDP ≤12 derived mmHg
- Outcome
- Correlation of predicted LVEDP with invasive LVEDP
Main finding
As reported in the abstract
Pearson's correlation coefficient
0.83
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted hazard ratio (95% CI) | |
|---|---|---|
| Composite outcome (hospitalized heart failure or all-cause death) · mean follow-up of 8.1 ± 3.9 yearspLVEDP 13-18 derived mmHgvs pLVEDP ≤12 derived mmHgElevated pLVEDP was an independent risk factor | 2.10 (1.30–3.42) | |
| Composite outcome (hospitalized heart failure or all-cause death) · mean follow-up of 8.1 ± 3.9 yearspLVEDP >18 derived mmHgvs pLVEDP ≤12 derived mmHgElevated pLVEDP was an independent risk factor | 4.33 (2.44–7.68) | |
| 0.10.31310Adjusted hazard ratio (log scale) |
- Composite outcome (hospitalized heart failure or all-cause death) — subjects developed the composite outcome
- 99 (18%)
NT-proBNP, LA reservoir strain, LV longitudinal strain by pLVEDP
- Higher NT-proBNP with elevated pLVEDP
- P < 0.001
- Lower LA reservoir strain with elevated pLVEDP
- P = 0.001
- Lower LV longitudinal strain with elevated pLVEDP
- P < 0.001
Composite outcome (hospitalized heart failure or all-cause death) · mean follow-up of 8.1 ± 3.9 years
- Patients with pLVEDP ≤12 derived mmHg had excellent event-free survival
Original publication
Estimated left ventricular end diastolic pressure by mean left atrial transit time predicts adverse clinical outcome risk. Eur Heart J Cardiovasc Imaging. Published 26 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →