Estimating the Proportion of Adverse Pregnancy Outcomes Prevented With Improved Early Pregnancy Cardiovascular Health
Authors' conclusion
In this cohort of nulliparous pregnant individuals, potential benefits of improving maternal CVH to reduce APOs are considerable.
Study context
- Population
- Pregnant participants ≥18 years and without prepregnancy hypertension or gestational diabetes from the Nulliparous Pregnancy Outcomes Study
- Participants
- 8,927 participants
- Exposure
- Association of early pregnancy cardiovascular health (CVH) and adverse pregnancy outcomes (APOs); impact fractions for hypothetical improvement of maternal CVH
- Outcome
- APO risk per lower CVH score
Main finding
As reported in the abstract
Adjusted OR (lower CVH score, higher APO risk)
1.46; 95% CI: 1.39-1.54
Observational data: associations, not effects.
Further findings
Proportion of APOs prevented, CVH score <50 shifted to 50 points (5.8% of participants)
- APOs prevented
- 12%
- Hypothetical intervention
Proportion of APOs prevented, CVH score <80 shifted to 80 points (51.4% of participants)
- APOs prevented
- 15%
- Hypothetical intervention
- Dose-response relationship
Proportion of APOs prevented, everyone shifted to 100 points (96.6% of participants)
- APOs prevented
- 40%
- Hypothetical intervention
- Dose-response relationship
APO subtypes
- Similar findings were observed for each APO subtype
Participant characteristics
- Age
- 27.2 years (SD: 5.4)
- Experienced an APO
- 25.3%
Original publication
Estimating the Proportion of Adverse Pregnancy Outcomes Prevented With Improved Early Pregnancy Cardiovascular Health. JACC Adv. Published 17 January 2026. doi:10.
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