Cardio-oncology & otherCohort study
Adverse pregnancy outcomes in successive pregnancies and maternal cardiovascular mortality: a Norwegian nationwide study
- Nationwide registry-based cohort study
- registry linkage
Authors' conclusion
Considering APO sequence across complete pregnancy histories provides more detailed CVD information than binary classification.
Study context
- Population
- Women with complete pregnancy histories, Medical Birth Registry of Norway (1967–2020)
- Participants
- 1,001,409 women
- Exposure
- APO sequence and lifetime parity categories vs multiparous women without adverse pregnancy outcomes (APOs)
- Outcome
- Premature CVD mortality (≤70 years)
Main finding
As reported in the abstract
CVD mortality, composite APOs
Each group vs multiparous without APOsAdjusted hazard ratio (95% CI)
APO first, no further pregnancieshighest
3.30(2.97–3.66)
APO first and later
2.41(2.16–2.69)
APO later only
1.65(1.50–1.81)
One uncomplicated pregnancy
1.83(1.69–1.97)
APO first, then uncomplicatedlowest
1.39(1.27–1.53)
Observational data: associations, not effects.
Further findings
Cardiovascular disease (CVD) mortality, binary classification (APO presence vs absence)
- Binary classification indicated an overall 1.73-fold higher CVD mortality
- 1.73 (95% CI 1.64-1.84)
Individual APOs
- Similar patterns observed across individual APOs
Original publication
Adverse pregnancy outcomes in successive pregnancies and maternal cardiovascular mortality: a Norwegian nationwide study. Eur Heart J. Published 5 August 2026. doi:10.1093/eurheartj/ehag564
Summarised from the published abstract; every number is checked against it