Heart failure & cardiomyopathies
Ethnic Differences in Protein Biomarkers of Peripartum Cardiomyopathy: A Proteomic Study on the EURObservational Research Programme (EORP) Cohort
Authors' conclusion
QSOX1, ADIPOQ and ITIH3 exhibited consistent expressions across ethnic groups
Study context
- Population
- Women with peripartum cardiomyopathy (PPCM) in the EURObservational Research Programme
- Participants
- 82 women7 countries
- Exposure
- Serum biomarker profiles across self-reported ethnic groups
- Outcome
- Ethnic differences in serum biomarker profiles (principal component analysis (PCA) clustering by ethnicity)
- Follow-up
- At diagnosis
Methodological detailsmultinational registry cohort, 7 countries, EORP registry, Ethnicity self-reported, DIA-based label-free LC-MS proteomics; Spectronaut v15
- Multinational registry cohort
- 7 countries
- EORP registry
- Ethnicity self-reported
- DIA-based label-free LC-MS proteomics; Spectronaut v15
Main finding
As reported in the abstract
Clustering by ethnicity on PCA
Variance explained by PC1
15.2%
Variance explained by PC2
12.0%
Observational data: associations, not effects.
Further findings
Baseline characteristics
- Mean age (years)
- 30.5 ± 6.7
- No hypertension during pregnancy
- 75%
- Median LVEF (IQR 27.0-41.1), no ethnic differences
- 35%
- More severe LV dilatation in Middle Eastern women
Original publication
Ethnic Differences in Protein Biomarkers of Peripartum Cardiomyopathy: A Proteomic Study on the EORP Cohort. ESC Heart Fail. Published 4 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →