Heart failure & cardiomyopathies
Proteomic Profiling in Patients With Peripartum Cardiomyopathy: A Biomarker Study of the ESC EORP PPCM Registry
Authors' conclusion
Salient biologic themes related to immune response proteins, inflammation, fibrosis, angiogenesis, apoptosis, and coagulation were predominant in patients with PPCM compared with HCs.
Study context
- Population
- Patients with newly diagnosed peripartum cardiomyopathy and matched healthy postpartum mothers
- Participants
- 84 vs 29
- Comparison
- PPCM vs postpartum healthy controls
- PPCMn = 84
- Healthy controls (HCs)n = 29reference
- Outcome
- Serum proteome profile and diagnostic performance (AUC) of protein biomarkers to distinguish PPCM from HCs
Methodological detailsuntargeted serum proteome profiling, matched healthy controls, 10-fold cross-validation
- Untargeted serum proteome profiling
- Matched healthy controls
- 10-fold cross-validation
Main finding
As reported in the abstract
Differentially up-regulated proteins in PPCM vs HCs
15
Differentially down-regulated proteins in PPCM vs HCs
14
Proteins significant by Boruta algorithm
7
AUC of adiponectin + quiescin sulfhydryl oxidase 1 + inter-α-trypsin inhibitor heavy chain + NT-proBNP (best diagnostic precision), 95% CI 0.84-0.96
0.90
Observational data: associations, not effects.
Further findings
Mean
| Outcome | PPCM | HCs | P value |
|---|---|---|---|
| LVEF | 33.5% (SD 9.3%) | 57.0% (SD 8.8%) | P < 0.001 |
Original publication
Proteomic Profiling in Patients With Peripartum Cardiomyopathy: A Biomarker Study of the ESC EORP PPCM Registry. JACC Heart Fail. Published 4 October 2023. doi:10.
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