Heart failure & cardiomyopathies
Evaluating the Prognostic Value of Systemic Immune-Inflammatory Index in Patients with Acute Decompensated Heart Failure
Main finding · 30-day mortalityResult — go to the resultHazard ratio 2.03 95% CI 1.34–3.08Authors' conclusion
This study found a significant positive association between SII and 30 day all-cause mortality in ADHF patients. We determined the SII cut-off point for predicting 30 day all-cause mortality in patients with ADHF to be 980 × 109/L.
Study context
- Population
- Patients hospitalised for acute decompensated HF (China Jiangxi-ADHF1 project)
- Participants
- 1,452 patients
- Exposure
- High SII vs low SII
- Outcome
- All-cause mortality
- Follow-up
- 30 days
Main finding
30-day mortality
Hazard ratio
2.03
95% CI 1.34–3.08
Higher SII
HR 2.03 (95% CI 1.34–3.08)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| Prediction of 30-day mortality (ROC) | SII AUC 0.7479 · Optimal threshold 980 × 109/L · Sensitivity 0.7547 · Specificity 0.7234 |
Dose-response (restricted cubic spline)
- Non-linear dose-response relationship between SII and 30-day mortality (P for non-linear)
- 0.006
Original publication
Evaluating the Prognostic Value of Systemic Immune-Inflammatory Index in Patients with Acute Decompensated Heart Failure. ESC Heart Fail. Published 12 June 2024. doi:10.
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