Arrhythmias & electrophysiology
Evaluation of the association between circulating IL-1β and other inflammatory cytokines and incident atrial fibrillation in a cohort of postmenopausal women
Main finding · Incident AF per 1 log (pg/mL) increase in baseline IL-1βResult — go to the resultHazard ratio 0.86Authors' conclusion
In this large cohort of postmenopausal women, there was no significant association between IL-1β and incident AF, although downstream effectors, CRP and IL-6, were associated with incident AF.
Study context
- Population
- Postmenopausal women from the Women's Health Initiative3,943 developed atrial fibrillation (AF)
- Participants
- 16,729 women
- Exposure
- Baseline IL-1β and incident AF
- Outcome
- Incident AF
- Follow-up
- Average 8.5 years
Methodological detailsWomen's Health Initiative cohort, multivariable-adjusted Cox regression
- Women's Health Initiative cohort
- Multivariable-adjusted Cox regression
Main finding
As reported in the abstract
Incident AF per 1 log (pg/mL) increase in baseline IL-1β
Hazard ratio
0.86
P = 0.24
Observational data: associations, not effects.
Further findings
Other inflammatory cytokines (IL-7, IL-8, IL-10, IGF-1, TNF-α) and incident AF
- Not significantly associated with incident AF, similar to IL-1β
C-reactive protein (CRP) and IL-6 and incident AF
- Significant associations with incident AF
Original publication
Evaluation of the association between circulating IL-1β and other inflammatory cytokines and incident atrial fibrillation in a cohort of postmenopausal women. Am Heart J. Published 13 January 2023. doi:10.
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