Heart failure & cardiomyopathies

Exercise-Based Cardiac Rehabilitation for Adults with Heart Failure – 2023 Cochrane Systematic Review and Meta-Analysis

Eur J Heart FailPublished Systematic review and meta-analysis of randomised trials

Study context

Population
Adults with heart failure (HF) in RCTs with follow-up ≥6 months
Participants
8,728 adults60 RCTs
Comparison
ExCR vs no-exercise control
Outcome
Mortality, hospitalization and HRQoL
Follow-up
Short term (≤12 months)
Methodological detailsCochrane review update, stratified by delivery mode
  • Cochrane review update
  • Stratified by delivery mode

Pooled result

As reported in the abstract

ExCR vs ControlRelative risk (95% CI)
All-cause mortality
0.93(0.71–1.21)
All-cause hospitalization; NNT 13 (95% CI 9-22)
0.69(0.56–0.86)
ExCR vs ControlMean difference (95% CI)
MLWHF overall score (HRQoL)
−7.39(−10.30 to −4.47)

Further pooled results

All-cause mortality, all-cause hospitalization, MLWHF overall score (long term) · long-term follow-up (>12 months)

Long-term mortality, RR
0.87 (95% CI 0.72-1.04)
Long-term all-cause hospitalization, RR
0.84 (95% CI 0.70-1.01)
Long-term MLWHF overall score
−9.59 (95% CI −17.48 to −1.50)
A similar pattern of results was seen in the long term

Outcomes by delivery mode

Improvements with ExCR seen across centre, home (including digitally supported) and hybrid settings

Original publication

Exercise-Based Cardiac Rehabilitation for Adults with Heart Failure – 2023 Cochrane Systematic Review and Meta-Analysis. Eur J Heart Fail. Published 31 October 2023. doi:10.1002/ejhf.3046

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