Heart failure & cardiomyopathies
Left atrial strain in acute heart failure: clinical and prognostic insights
Authors' conclusion
In AHF of any LVEF, LA dynamics is highly predictive of re-hospitalization and cardiovascular outcome and allows to ease risk-stratification
Study context
- Population
- Consecutive acute heart failure (AHF) patients with reduced, mildly reduced and preserved left ventricular ejection fraction (LVEF) (LAS-AHF trial)77 followed up
- Participants
- 85 patients
- Exposure
- Left atrial strain (LAS) above vs below cut-off values
- Outcome
- Time to first re-hospitalization, worsening HF or CV death
- Follow-up
- 12 months
Methodological detailsconsecutive patients, speckle tracking echocardiography
- Consecutive patients
- Speckle tracking echocardiography
Main finding
As reported in the abstract
Re-hospitalization, worsening HF or CV death
Hazard ratio (95% CI)P value
LAS >16%vs LAS ≤16%log-rank; better survival with LAS >16%
3.5(1.8–7.3)
P = 0.004LAS improvement > 5%vs LAS improvement ≤5%log-rank; better survival with improvement > 5%
3.6(2–7.9)
P < 0.01LAS/LAVi >0.25%/mL/m²vs LAS/LAVi ≤0.25%/mL/m²log-rank; better survival with ratio >0.25%/mL/m²
3.27(1.4–7.7)
P = 0.007- CV events at 12 months
- 24
Observational data: associations, not effects.
Further findings
Change from admission to discharge
- Right ventricular (RV) function significantly improved after decongestion
- No significant differences in left atrial (LA) dynamics and left ventricular (LV) function
LAS and LA pump strain rate (sinus rhythm, mild or no mitral regurgitation subgroup) · during hospitalization
- Decongestion associated with significant improvement of LAS and LA pump strain rate
Original publication
Left atrial strain in acute heart failure: clinical and prognostic insights. Eur Heart J Cardiovasc Imaging. Published 31 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →