Arrhythmias & electrophysiology
Exercise-Induced QRS Prolongation in Brugada Syndrome: Implications for Improving Disease Phenotyping and Diagnosis
Authors' conclusion
Exercise-induced QRSd prolongation is ubiquitous in BrS primarily owing to delayed right ventricular activation. This electrocardiogram phenotype predicts a positive procainamide response
Study context
- Population
- Patients with Brugada syndrome and controls undergoing exercise stress testing with digital 12-lead ECG
- Participants
- 53 vs 52
- Comparison
- Brugada syndrome (BrS) vs controls
- BrSn = 53
- Controlsn = 52reference
- Outcome
- Exercise-induced change in QRS duration (QRSd) in V6
- Follow-up
- Baseline, peak exercise and recovery
Methodological detailstest and validation cohorts
- Test and validation cohorts
Main finding
As reported in the abstract
Exercise-induced change in QRSd in V6
BrS
7.1
SD 6.5 · ms
Controls
−6.1
SD 6.0 · ms
P < 0.001
Observational data: associations, not effects.
Further findings
QRSd in recovery, V6
P = 0.002
Exercise-induced S wave duration prolongation in V6
P < 0.001
- Any exercise-induced QRS duration (QRSd) prolongation in V6 to predict positive procainamide response (suspected BrS): Test cohort Sensitivity 100% · Specificity 95%
- Any exercise-induced QRSd prolongation in V6 to predict positive procainamide response (suspected BrS): Validation cohort Sensitivity 87% · Specificity 93%
Baseline ECG parameters
- Similar between BrS and controls
Original publication
Exercise-Induced QRS Prolongation in Brugada Syndrome: Implications for Improving Disease Phenotyping and Diagnosis. JACC Clin Electrophysiol. Published 26 June 2024. doi:10.
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