Heart failure & cardiomyopathies

Exercise Training in Left Ventricular Assist Device Patients: Protocol of an Individual Participant Data Meta-Analysis

ESC Heart FailPublished Protocol of an individual participant data meta-analysis of randomised controlled trials

Authors' conclusion

Our study will be the first to harmonize IPD in meta-analysis to demonstrate the effects of exercise training on exercise performance and QoL over standard care in LVAD patients.

Study context

Population
Patients with left ventricular assist device (LVAD)
Comparison
Exercise training vs standard care
Methodological detailsrandom effects, one-stage and two-stage approaches, individual participant data (IPD) to be requested from corresponding authors of eligible RCTs, checked, recalculated, merged and screened for quality, risk of bias and heterogeneity
  • Random effects
  • One-stage and two-stage approaches
  • IPD to be requested from corresponding authors of eligible RCTs, checked, recalculated, merged and screened for quality, risk of bias and heterogeneity

Pooled result

As reported in the abstract

  • Expected: superior effects of exercise training on submaximal exercise capacity and quality of life (QoL), similar effects on maximal aerobic capacity vs standard care
  • Protocol; no results reported

Original publication

Exercise Training in Left Ventricular Assist Device Patients: Protocol of an Individual Participant Data Meta-Analysis. ESC Heart Fail. Published 25 September 2024. doi:10.1002/ehf2.15063

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