Heart failure & cardiomyopathies
Exercise training improves cardiovascular fitness in dilated cardiomyopathy caused by truncating titin variants
Primary result · Peak VO2Result — go to the resultDifference +2.9 mL/kg/min 95% CI +1.2 to +4.5Authors' conclusion
Our study shows that vigorous intensity exercise training improved peak VO2 in patients with DCM-TTNtv. Exercise training was associated with improved LV systolic function and increased blood volume and oxygen carrying capacity.
Study context
- Population
- Patients with dilated cardiomyopathy (DCM) caused by truncating titin variants (DCM-TTNtv), from outpatient clinics for inherited cardiac diseases13 completed
- Participants
- 14 patients
- Comparison
- Vigorous-intensity exercise training vs usual care
- Primary endpoint
- Change in peak oxygen uptake (VO2)
Methodological details8 weeks usual care followed by 8 weeks exercise training
- 8 weeks usual care followed by 8 weeks exercise training
Primary result
Peak VO2
Difference
+2.9 mL/kg/min
95% CI +1.2 to +4.5
P = 0.002
By group
Exercise training
+1.9
change · 95% CI +0.9 to +2.9 · mL/kg/min
As reported in the abstract
Secondary outcomes
Adaptations to exercise training
- Resting cardiac output
- +0.8 L/min, p=0.042
- Total blood volume
- +713 mL, p<0.001
- Total haemoglobin mass
- +73 g, p<0.001
- LVEF
- +3.2% (p=0.053)
- Global longitudinal strain
- −2.0% (p=0.044)
Safety
- No exercise-related adverse events or change in plasma biomarkers of cardiac or skeletal muscle damage
Original publication
Exercise training improves cardiovascular fitness in dilated cardiomyopathy caused by truncating titin variants. Heart. Published 24 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →