Exploring the Link Between Genetic Predictors of Cardiovascular Disease and Psoriasis
Authors' conclusion
Findings of this mendelian randomization study indicate that genetic predictors of cardiovascular disease were associated with increased psoriasis risk with no reciprocal effect or association with other IMIDs.
Study context
- Population
- Individuals of European descent from GWAS meta-analyses of coronary artery disease (CAD), stroke, psoriasis and 9 other immune-mediated diseases (IMIDs)
- Participants
- ≈3,400,000 individuals
- Comparison
- Genetic predictors of CAD and stroke vs risk of psoriasis and 9 other IMIDs (bidirectional)
- Outcome
- Associations of genetic predictors of CAD and stroke with risk of psoriasis and 9 other IMIDs (inverse-variance weighted (IVW) MR estimates)
Methodological details2-sample mendelian randomization, 2-sample mendelian randomization (MR), summary-level GWAS meta-analysis data, European descent, Data analyzed January 2023 to May 2024
- 2-sample mendelian randomization
- 2-sample MR
- Summary-level GWAS meta-analysis data
- European descent
- Data analyzed January 2023 to May 2024
Pooled result
As reported in the abstract
Psoriasis risk by genetic predictors of CVD (IVW MR)
IVW OR (95% CI)P value
CADgenetic predictors of CAD → psoriasis
1.07(1.04–1.10)
P = 0.003Strokegenetic predictors of stroke → psoriasis
1.22(1.05–1.41)
P = 0.01Further pooled results
CAD and stroke (reverse direction: genetic predictors of psoriasis)
- Genetic predictors of psoriasis had no association with CAD or stroke
Other IMIDs incl. rheumatoid arthritis and inflammatory bowel disease
- No risk-increasing associations of genetic predictors of CVD
Original publication
Exploring the Link Between Genetic Predictors of Cardiovascular Disease and Psoriasis. JAMA Cardiol. Published 1 November 2024. doi:10.
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