Expression of Soluble ST2 in Patients with Essential Hypertension and its Relationship with Left Ventricular Hypertrophy
Main finding · LVHResult — go to the resultOdds ratio 2.990 95% CI 1.650–5.419Authors' conclusion
Up-regulation of sST2 is strongly related to LVH in EH patients, is an independent risk factor for hypertensive LVH, and can be used as a biomarker for the diagnosis of LVH.
Study context
- Population
- Patients with essential hypertension
- Participants
- 97 patients
- Exposure
- Left ventricular hypertrophy (LVH) vs non-LVH in essential hypertension
- LVHn = 52
- non-LVHn = 45reference
- Outcome
- Relationship between serum sST2 (ELISA) and LVH
Main finding
LVH
Odds ratio
2.990
95% CI 1.650–5.419
P < 0.001
LVHvs non-LVH in essential hypertension
OR 2.990 (95% CI 1.650–5.419); P < 0.001
As reported in the abstract
- Soluble ST2 (sST2) elevated in LVH vs non-LVH
- P < 0.001
- Correlation of sST2 with LV mass index (Pearson r)
- r = 0.454, P < 0.001
- AUC of sST2 for diagnosing LVH
- 0.767 (95% CI 0.669-0.866; P < 0.001)
- Sensitivity
- 0.808
- Specificity
- 0.689
Observational data: associations, not effects.
Original publication
Expression of Soluble ST2 in Patients with Essential Hypertension and its Relationship with Left Ventricular Hypertrophy. ESC Heart Fail. Published 9 October 2022. doi:10.
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