Heart failure & cardiomyopathies
External Validation of the Natriuretic Response Prediction Equation to Discriminate Diuretic Response in Heart Failure
Authors' conclusion
In this cohort of patients with ADHF, the NRPE outperformed spot urine sodium concentration and all other metrics related to diuretic response to predict poor natriuretic response.
Study context
- Population
- Patients admitted with acute decompensated HF requiring IV loop diuretics87 diuretic administrations analysed
- Participants
- 49 patients
- Comparison
- Natriuretic response prediction equation (NRPE) vs spot urine sodium vs urine output to predict poor natriuretic response
- Outcome
- Discrimination of poor loop diuretic natriuretic response (sodium output <50 mmol)
- Follow-up
- 6 h following diuretic administration
Methodological detailsexternal validation
- External validation
Performance
As reported in the abstract
Poor natriuretic response during 6-h urine collection · 6 h
| Test or model | AUC |
|---|---|
| NRPE | 0.91 (95% CI 0.85-0.98) |
| Spot urine sodium | 0.75 |
| Urine output | 0.74 |
AUC
NRPE0.91 (95% CI 0.85-0.98)
Spot urine sodium0.75
Urine output0.74
- Poor natriuretic response occurred in visits
- 39%
Original publication
External Validation of the Natriuretic Response Prediction Equation to Discriminate Diuretic Response in Heart Failure. ESC Heart Fail. Published 12 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →