Heart failure & cardiomyopathies
Heart Rate Reactivity, Recovery, and Endurance of the Incremental Shuttle Walk Test in Patients Prone to Heart Failure
Authors' conclusion
Spironolactone on top of usual treatment compared with usual treatment alone did not change resting HR, CHR, HRR and EE in response to ISWT.
Study context
- Population
- Patients prone to HF (≈70% on beta-blockers) who completed the incremental shuttle walk test at baseline, month 1 and month 9527 randomised in HOMAGE
- Participants
- 114 vs 113
- Comparison
- Spironolactone plus usual treatment vs usual treatment alone
- Spironolactonen = 114
- Controln = 113reference
- Primary endpoint
- Changes in chronotropic HR reactivity, HR recovery and exercise endurance on the incremental shuttle walk test
- Follow-up
- Months 1 and 9
Methodological detailsopen, sub-study
- Open
- Sub-study
Primary result
As reported in the abstract
Resting HR, chronotropic HR reactivity, HR recovery and exercise endurance, between groups
Resting HR and chronotropic HR reactivity did not change from baseline, except a small decrease in HR immediately post-exercise in controls at month 9
−3.11 b.p.m.
Further findings
Subgroups by sex, age, LVEF or GFR
- Subgroup analyses were confirmatory
Pooled values, both groups, baseline and months 1 and 9
- Resting HR
- 61.5 b.p.m.
- Chronotropic HR reactivity
- 20.0 b.p.m.
- HR recovery at 1 min
- 9.07 b.p.m.
- HR recovery at 5 min
- 13.8 b.p.m.
- Exercise endurance
- 48.3 shuttles
- Mean
Original publication
Heart Rate Reactivity, Recovery, and Endurance of the Incremental Shuttle Walk Test in Patients Prone to Heart Failure. ESC Heart Fail. Published 11 August 2024. doi:10.
Summarised from the published abstract; every number is checked against it