External Validation of the Veterans Affairs Women Cardiovascular Disease Risk Score to Nonveteran Women
Authors' conclusion
The calibrated VA women CVD risk score can serve as a validated clinical decision-making tool to screen and assess the CVD risk of nonveteran women-civilian and younger active-duty military service members.
Study context
- Population
- Civilian women (Dallas Heart Study) and young active-duty women military service members (Department of Defense and Veterans Affairs Infrastructure for Clinical Intelligence Direct Care)two external validation populations · civilians (Dallas Heart Study) 1,383 · young active-duty military service members (Department of Defense and Veterans Affairs Infrastructure for Clinical Intelligence Direct Care) 154,168
- Predictors
- Veterans Affairs (VA) women cardiovascular disease (CVD) risk score
- Predicted outcome
- ten-year atherosclerosis CVD (ASCVD) risk
Methodological detailslinear calibration models applied to the Cox model stratified by race and ethnicity group, log-likelihood ratio tests
- Linear calibration models applied to the Cox model stratified by race and ethnicity group
- Log-likelihood ratio tests
Model performance
As reported in the abstract
Met the good discrimination criterion across all 3 race and ethnic groups in both external populations
C-statistics ≥0.7
Further findings
Calibration in-the-large (simple update of atherosclerosis CVD (ASCVD) event-free survival)
- Preserved accuracy for all races for civilian and young women military service members, except Hispanic civilian women who needed recalibration
Original publication
External Validation of the Veterans Affairs Women Cardiovascular Disease Risk Score to Nonveteran Women. JACC Adv. Published 12 August 2025. doi:10.
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