International patterns in lipid management and implications for patients with coronary heart disease: results from the INTERASPIRE study
Authors' conclusion
In this international study, contemporary lipid goals were not achieved in most CHD patients, with lower-middle-income countries having the worst goal attainment.
Study context
- Population
- Patients aged 18–79 years hospitalized with coronary heart disease (CHD) in the preceding 6–36 months, 14 countries from all WHO regions (2020–23)valid lipid data from 13 countries
- Participants
- 4,061 patients
- Outcome
- LLT use and attainment of 2019 EAS/ESC lipid goals (LDL-C < 1.4 mmol/L, non-HDL-C < 2.2 mmol/L, apolipoprotein B (apoB) <65 mg/dL)
Methodological detailsinternational, 14 countries, central laboratory analyses
- International
- 14 countries
- Central laboratory analyses
Main finding
As reported in the abstract
- Low-density lipoprotein cholesterol (LDL-C) goal attainment
- 17.5%
- Non-HDL-C goal attainment
- 29.9%
- ApoB goal attainment
- 29.2%
- High-intensity statin monotherapy (inter-country range 5.3%-77.3%)
- 49.6%
- Low/moderate-intensity statin monotherapy (inter-country range 5.1%-70.1%)
- 24.1%
- Combination therapy (inter-country range 0.2%-41.1%)
- 12.2%
- No lipid-lowering therapies (LLT) (inter-country range 3.5%-36.7%)
- 12.7%
- No change in treatment intensity between index event and interview
- 66.3%
Observational data: associations, not effects.
Further findings
Goal attainment by country income level
- Higher-income countries did better in goal attainment than lower-middle-income countries
Original publication
International patterns in lipid management and implications for patients with coronary heart disease: results from the INTERASPIRE study. Eur J Prev Cardiol. Published 12 August 2025. doi:10.
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