Acute cardiac care & resuscitation
External validation of the simple NULL-PLEASE clinical score in predicting outcomes in men and women with out-of-hospital cardiac arrest: a nationwide registry-based study
Authors' conclusion
In a nationwide OHCA-cohort, the predictive ability of the NULL-PLEASE score was higher in men than in women.
Study context
- Population
- Out-of-hospital cardiac arrest (OHCA) patients with return of spontaneous circulation (ROSC) or ongoing CPR at hospital arrival, Danish nationwide registries, 2001–2019
- Participants
- 2,599 vs 1,280
- Exposure
- NULL-PLEASE score performance in men vs women
- Menn = 2,599
- Womenn = 1,280
- Outcome
- 1-day mortality (predictive ability of NULL-PLEASE score, AUCROC)
- Follow-up
- 1 day
Methodological detailsnationwide registry-based, external validation
- Nationwide registry-based
- External validation
Main finding
As reported in the abstract
1-day mortality
| Group | Value | AUCROC |
|---|---|---|
| Men | 36% | 0.828 (95% CI: 0.813-0.844) |
| Women | 50% | 0.754 (95% CI: 0.728-0.780) |
Value
Men36%
Women50%
AUCROC
Men0.828 (95% CI: 0.813-0.844)
Women0.754 (95% CI: 0.728-0.780)
- Interaction between NULL-PLEASE score and sex, 1-day mortality
- P < 0.001
Observational data: associations, not effects.
Secondary outcomes
30-day mortality
1-year mortality or anoxic brain damage
- 30-day mortality — Interaction between NULL-PLEASE score and sex
- P = 0.04
- 1-year mortality or anoxic brain damage — Interaction between NULL-PLEASE score and sex
- P = 0.09
Predictive ability for secondary outcomes
- Results were similar for secondary outcomes
Original publication
External validation of the simple NULL-PLEASE clinical score in predicting outcomes in men and women with out-of-hospital cardiac arrest: a nationwide registry-based study. Eur Heart J Acute Cardiovasc Care. Published 5 May 2025. doi:10.
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