Acute cardiac care & resuscitation
Extracorporeal life support in cardiac arrest: a post hoc Bayesian re-analysis of the INCEPTION trial
Authors' conclusion
Bayesian re-analysis of the INCEPTION trial estimated a 42% probability of an MCID between ECPR and CCPR in refractory OHCA in terms of 30-day survival with a favourable neurologic outcome.
Study context
- Population
- Patients with refractory out-of-hospital cardiac arrest (OHCA)
- Comparison
- Extracorporeal cardiopulmonary resuscitation (ECPR) vs conventional cardiopulmonary resuscitation (CCPR)
- Primary endpoint
- Survival with favourable neurologic outcome (cerebral performance category 1-2)
- Follow-up
- 30 days
Methodological detailspost hoc Bayesian re-analysis, multicentre, minimally informative prior, sensitivity analyses under sceptical and literature-based priors
- Post hoc Bayesian re-analysis
- Multicentre
- Minimally informative prior
- Sensitivity analyses under sceptical and literature-based priors
Primary result
As reported in the abstract
30-day survival with favourable neurologic outcome
ECPR vs CCPRMean ARD (95% CrI)
CrI; favouring ECPR
3.6%(−9.5-16.7%)
ECPR vs CCPRMedian relative risk (95% CrI)
CrI
1.22(0.59–2.51)
- Posterior probability of minimal clinically important difference (MCID) (5% ARD) in favour of ECPR
- 42%
Further findings
Survival with favourable neurologic outcome · 6 months
- Posterior probability of MCID (5% ARD) in favour of ECPR
- 42%
Original publication
Extracorporeal life support in cardiac arrest: a post hoc Bayesian re-analysis of the INCEPTION trial. Eur Heart J Acute Cardiovasc Care. Published 24 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →