Acute cardiac care & resuscitation
Impact of extracorporeal cardiopulmonary resuscitation on neurological prognosis and survival in adult patients after cardiac arrest: An individual pooled patient data meta-analysis
Pooled result · Unfavourable neurological outcomeResult — go to the resultOdds ratio 0.68 95% CI 0.53–0.87Authors' conclusion
This IPDMA showed that ECPR was associated with significantly lower rates of unfavorable neurological outcome and mortality in refractory CA.
Study context
- Population
- Adults after cardiac arrest17 studies, matched
- Participants
- 2,064 adults
- Comparison
- ECPR vs conventional cardiopulmonary resuscitation (CCPR)
- ECPRn = 1,031
- CCPRn = 1,033reference
- Outcome
- Unfavourable neurological outcome (Cerebral Performance Category 3-5)
- Follow-up
- Collected at different time-points
Methodological detailspropensity-score matched (observational studies, 1:1), Search of PubMed, EMBASE and CENTRAL up to 20 October 2022
- Propensity-score matched (observational studies, 1:1)
- Search of PubMed, EMBASE and CENTRAL up to 20 October 2022
Pooled result
Unfavourable neurological outcome
Odds ratio
0.68
95% CI 0.53–0.87
P = 0.002
Events by group
ECPR vs CCPR
OR 0.68 (95% CI 0.53–0.87); P = 0.002
As reported in the abstract
Further pooled results
| Outcome | ECPR | CCPR | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| Mortality | 77.9% | 83.3% | 0.68 (0.54–0.86) | P = 0.001 | |
| 0.512Odds ratio (log scale) |
Prespecified subgroups
- Results consistent across most prespecified subgroups; odds influenced by initial rhythm, cause of arrest and combinations of lactate on admission and resuscitation duration
Original publication
Impact of extracorporeal cardiopulmonary resuscitation on neurological prognosis and survival in adult patients after cardiac arrest: An individual pooled patient data meta-analysis. Resuscitation. Published 12 August 2024. doi:10.
Summarised from the published abstract; every number is checked against it