Acute cardiac care & resuscitation
Extracorporeal Membrane Oxygenation in the Therapy of Cardiogenic Shock: 1-Year Outcomes of the Multicentre, Randomized ECMO-CS Trial
Primary result · All-cause deathResult — go to the resultHazard ratio 1.02 95% CI 0.66–1.58Authors' conclusion
Among patients with severe or rapidly progressing cardiogenic shock, immediate initiation of ECMO did not improve clinical outcomes at 1 year compared to the early conservative strategy.
Study context
- Population
- Patients with severe or rapidly progressing cardiogenic shock
- Participants
- 117 patients
- Comparison
- Immediate extracorporeal membrane oxygenation (ECMO) vs early conservative strategy
- ECMOn = 58
- Early conservativen = 59reference
- Primary endpoint
- All-cause mortality
- Follow-up
- 1 year
Methodological detailsmulticentre, 1-year follow-up
- Multicentre
- 1-year follow-up
Primary result
All-cause death
Hazard ratio
1.02
95% CI 0.66–1.58
P = 0.93
Events by treatment group
ECMOvs Early conservative
HR 1.02 (95% CI 0.66–1.58); P = 0.93
As reported in the abstract
Secondary outcomes
| Outcome | ECMO | Early conservative | HR (95% CI) | P value | |
|---|---|---|---|---|---|
| Composite of death, resuscitated cardiac arrest or another mechanical circulatory support device · 1 year | 74.1% | 79.7% | 0.83 (0.55–1.25) | P = 0.29 | |
| 0.512Hazard ratio (log scale) |
Duration of mechanical ventilation, intensive care unit (ICU) stay and hospital stay
- Comparable between groups
1-year mortality by baseline mean arterial pressure (MAP) (unplanned post-hoc subgroup analysis)
- Lower mortality with treatment strategy in low baseline MAP (<63 mmHg) subgroup
- HR 0.58, 95% CI 0.29-1.16
- Pinteraction = 0.017
- Unplanned post-hoc subgroup analysis
Original publication
Extracorporeal Membrane Oxygenation in the Therapy of Cardiogenic Shock: 1-Year Outcomes of the Multicentre, Randomized ECMO-CS Trial. Eur J Heart Fail. Published 8 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →