Acute cardiac care & resuscitation

Individualized Or Conventional Transfusion Strategy During Veno-Arterial Extracorporeal Membrane Oxygenation Support (ICONE Study): Rationale and Design of a Prospective Multicenter Randomized Controlled Trial

Am Heart JPublished multicenter, randomized, controlled trial

Study context

Population
Adult patients supported by veno-arterial extracorporeal membrane oxygenation (VA-ECMO) for refractory cardiogenic shockplanned sample size
Participants
236 patients
Planned comparison
individualized or conventional transfusion strategy
Primary endpoint
number of red blood cell (RBCs) units transfused per day of ECMO support
Methodological detailsstratified according to postcardiotomy versus medical etiology, rationale and design; currently recruiting
  • Stratified according to postcardiotomy versus medical etiology
  • Rationale and design; currently recruiting

No results yet. This paper sets out the design of a trial; its results are to come.

Original publication

Individualized Or Conventional Transfusion Strategy During Veno-Arterial Extracorporeal Membrane Oxygenation Support (ICONE Study): Rationale and Design of a Prospective Multicenter Randomized Controlled Trial. Am Heart J. Published 28 September 2026. doi:10.1016/j.ahj.2026.107616

Summarised from the published abstract; every number is checked against it

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