Heart failure & cardiomyopathies
Factors Associated with the Use of Guideline-Directed Medical Therapy in Patients with Left Ventricular Assist Device
Authors' conclusion
While advancing age is associated with lower use of GDMT in HM3 recipients, other patient factors do not adequately explain low prescription rates.
Study context
- Population
- Patients with a HeartMate 3 (HM3) left ventricular assist device (LVAD)
- Participants
- 270 patients
- Outcome
- Patient factors associated with GDMT use (GDMT score 0-8)
- Follow-up
- Past 12 months
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Median guideline-directed medical therapy (GDMT) score
- 3 ± 1.7
- GDMT score of 3 or lower
- 155 patients (57.4%)
- Beta-blocker (BB) prescription rate
- 50%
- ACEi/ARB/angiotensin receptor-neprilysin inhibitor (ARNI) prescription rate
- 74.1%
- SGLT2i prescription rate
- 14.8%
- Mineralocorticoid receptor antagonist (MRA) prescription rate
- 47%
- ISDN/HYD prescription rate
- 19.6%
Observational data: associations, not effects.
Further findings
Predictors of individual drug use (multivariable)
- RV dysfunction linked to non-use of BB
- Age and Black race associated with non-use of MRA and use of ISDN/HYD
- No significant predictors for other therapies
Original publication
Factors Associated with the Use of Guideline-Directed Medical Therapy in Patients with Left Ventricular Assist Device. Eur J Heart Fail. Published 17 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →