Heart failure & cardiomyopathies
Gut Microbiota and Risk of Heart Failure in European Population—A Comprehensive Mendelian Randomization Study
Authors' conclusion
We identified seven intestinal microbiomes that were causally associated with HF at the level of gene prediction. This study will help with the discovery of potential preventive and therapeutic targets for HF.
Study context
- Population
- Individuals of European ancestry; genetic variants for 196 bacterial taxa from MiBioGen consortium (exposure) and heart failure (HF) summary statistics from HERMES consortium (outcome)
- Comparison
- Genetically predicted gut microbiota taxa and risk of HF
- Outcome
- Microbiomes associated with HF
Main finding
As reported in the abstract
- Seven microbiomes were found to be associated with HF
Further findings
| Outcome | OR | P value |
|---|---|---|
| HF risk, per taxon (higher risk)Order_Selenomonadales · higher risk of HF | 1.11 | P = 0.024 |
| HF risk, per taxon (higher risk)Family_Peptococcaceae · higher risk of HF | 1.07 | P = 0.045 |
| HF risk, per taxon (higher risk)Genus_Eubacterium eligens group · higher risk of HF | 1.14 | P = 0.022 |
| HF risk, per taxon (higher risk)Genus_Eubacterium oxidoreducens group · higher risk of HF | 1.12 | P = 0.011 |
| HF risk, per taxon (higher risk)Genus_Flavonifractor · higher risk of HF | 1.14 | P = 0.012 |
| HF risk, per taxon (lower risk)Genus_Anaerostipes · lower risk of HF | 0.90 | P = 0.014 |
| HF risk, per taxon (lower risk)Order_Bacillales · lower risk of HF | 0.95 | P = 0.042 |
Pleiotropy and heterogeneity
- Evidence of pleiotropy or heterogeneity was not observed
Original publication
Gut Microbiota and Risk of Heart Failure in European Population—A Comprehensive Mendelian Randomization Study. ESC Heart Fail. Published 17 March 2025. doi:10.
Summarised from the published abstract; every number is checked against it