Heart failure & cardiomyopathies
Factors Influencing Left Ventricular Thrombus Resolution and Its Significance on Clinical Outcomes
Main finding · Primary outcomeResult — go to the resultHazard ratio 0.45 95% CI 0.21–0.98Authors' conclusion
This study suggests that LVT resolution is an important predictor for favourable clinical outcomes.
Study context
- Population
- Patients with left ventricular thrombus (LVT) and LVEF <50% on transthoracic echocardiography, 2010–2021
- Participants
- 212 patients
- Exposure
- LVT resolution vs no LVT resolution
- LVT resolutionn = 179
- Outcome
- Composite of:
- All-cause death
- Stroke
- TIA
- Arterial thromboembolic events
- Follow-up
- Median 4.0 years (IQR 1.9 to 7.3 years)
Methodological detailssingle tertiary centre
- Single tertiary centre
Main finding
Primary outcome
Hazard ratio
0.45
95% CI 0.21–0.98
P = 0.045
LVT resolutionvs No LVT resolution
HR 0.45 (95% CI 0.21–0.98); P = 0.045
As reported in the abstract
- Primary outcomes in all patients
- 32 patients (15.1%)
Observational data: associations, not effects.
Further findings
LVT resolution
| HR (95% CI) | P value | ||
|---|---|---|---|
| LVEF improvement failure within 6 monthsHindering LVT resolution | 0.52 (0.31–0.85) | P = 0.010 | |
| 0.20.5125Hazard ratio (log scale) |
LVT recurrence after resolution
| HR (95% CI) | P value | ||
|---|---|---|---|
| LVEF improvement failure at LVT resolution | 3.10 (1.23–7.78) | P = 0.016 | |
| 0.10.31310Hazard ratio (log scale) |
Patients
- LVT resolution — LVT resolution observed
- 179 (84.4%)
- LVT recurrence after resolution — LVT recurrence
- 20 (11.2%)
LVT recurrence after resolution
- Discontinuation or duration of anticoagulation after resolution not significant predictors
Original publication
Factors Influencing Left Ventricular Thrombus Resolution and Its Significance on Clinical Outcomes. ESC Heart Fail. Published 3 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →