Heart failure & cardiomyopathiesCohort study
Clinical and Echocardiographic Factors Associated With Left Ventricular Thrombus Recurrence
- multicenter, retrospective cohort
Authors' conclusion
In this population, LVT recurred in 14% of patients and was associated with LV apical aneurysm and prior stroke, whereas lower rates of recurrence were associated with higher LVEF and continuation of OAC. Echocardiographic characteristics at the time of LVT resolution were associated with LVT recurrence.
Study context
- Population
- Patients with resolved LVT, diagnosed by echocardiographymean age 64.5 years, 78.6% male
- Participants
- 252 patients
- Exposure
- Clinical and echocardiographic characteristics at LVT diagnosis and resolution, evaluated for association with recurrence
- recurrent LVTn = 36
Main finding
As reported in the abstract
LVT recurrence
LVT recurred
36 (14.3%)
Observational data: associations, not effects.
Further findings
LVEF at LVT resolution
LV apical aneurysm at LVT resolution
Determinants of LVT recurrence (multivariable analysis)
| Comparison | HR (95% CI) | |
|---|---|---|
| LV apical aneurysm · higher rates of recurrence · Multivariable Cox proportional hazards regression | 3.12 (1.43–6.84) | |
| previous ischemic stroke · higher rates of recurrence · Multivariable Cox proportional hazards regression | 2.75 (1.22–6.17) | |
| OAC continuation · decreased recurrence · Multivariable Cox proportional hazards regression | 0.27 (0.13–0.58) | |
| 0.10.31310Hazard ratio (log scale) |
| Outcome | HR (per 1% increase) (95% CI) | |
|---|---|---|
| Determinants of LVT recurrence (multivariable analysis) — higher LVEF · decreased recurrence · Multivariable Cox proportional hazards regression | 0.96 (0.95–0.99) | |
| 0.512Hazard ratio (log scale) |
- LV ejection fraction (LVEF) at LVT resolution: P = 0.04
- Left ventricular (LV) apical aneurysm at LVT resolution: P = 0.001
LV systolic function at presentation
- similar between those with and without recurrence
Continuing oral anticoagulation (OAC) after LVT resolution
- Continuing OAC after LVT resolution was associated with less recurrence
- 54.7% vs 25.0%
- P = 0.005
Original publication
Clinical and Echocardiographic Factors Associated With Left Ventricular Thrombus Recurrence. JACC Adv. Published 17 June 2026. doi:10.1016/j.jacadv.2026.102873
Summarised from the published abstract; every number is checked against it