Outcomes Based on Angiographic vs Functional Significance of Complex 3-Vessel Coronary Disease: FAME 3 Trial
Authors' conclusion
By measuring the FSS, one can identify 50% of patients who have a similar outcome at 1 year with PCI compared with CABG. Lesions deferred from PCI based on FFR have a low event rate.
Study context
- Population
- Patients with angiographic 3-vessel coronary artery disease (CAD) eligible for coronary artery bypass grafting (CABG) (FAME 3 trial)
- Comparison
- Percutaneous coronary intervention (PCI) patients stratified by functional SYNTAX score (FSS) vs angiographic SYNTAX score (SS), each compared with CABG
Methodological detailsprespecified substudy
- Prespecified substudy
Primary result
As reported in the abstract
Primary endpoint · 1 year
PCI patients with FSS ≤22
50%
Further findings
MI and revascularization among all deferred lesions
- MI
- 0.5%
- Revascularization
- 3.2%
Original publication
Outcomes Based on Angiographic vs Functional Significance of Complex 3-Vessel Coronary Disease: FAME 3 Trial. JACC Cardiovasc Interv. Published 11 September 2023. doi:10.
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