Clinical Impact of Diabetes Mellitus After Intravascular Imaging–Guided Percutaneous Coronary Intervention (PCI) vs Coronary Artery Bypass Grafting
Authors' conclusion
In this hypothesis-generating study, PCI was associated with significantly higher risk for all-cause death, nonfatal myocardial infarction, or stroke at 3 years than CABG in DM patients with left main or 3-vessel disease. However, IVI-guided PCI had comparable risk for clinical events compared with CABG in DM patients.
Study context
- Population
- Diabetes mellitus (DM) patients with left main or 3-vessel disease (RENOVATE-COMPLEX-PCI trial and Samsung Medical Center registries)
- Participants
- 3,402 patients
- Comparison
- Intravascular imaging (IVI)-guided PCI vs angiography-guided PCI vs coronary artery bypass grafting (CABG)
- Outcome
- Composite of:
- All-cause death
- Nonfatal MI
- Stroke
- Follow-up
- 3 years
Methodological detailsindividual patient-level data, propensity-score matched analysis, hypothesis-generating
- Individual patient-level data
- Propensity-score matched analysis
- Hypothesis-generating
Pooled result
As reported in the abstract
Each group vs CABGHazard ratio (95% CI)P value
PCIall PCI 17.0% vs 12.4%
1.91(1.50–2.44)
P < 0.001IVI-guided PCI11.4% vs 12.4%
0.88(0.58–1.32)
P = 0.525Further pooled results
Primary outcome, propensity score-matched analysis · 3 years
- Propensity score-matched analysis yielded similar results
- HR: 0.85; 95% CI: 0.53-1.36; P = 0.507
Original publication
Clinical Impact of Diabetes Mellitus After Intravascular Imaging–Guided PCI vs Coronary Artery Bypass Grafting. JACC Cardiovasc Interv. Published 9 March 2026. doi:10.
Summarised from the published abstract; every number is checked against it