Valvular & structural heart diseaseMeta-analysis
Family screening for bicuspid aortic valve and aortic dilatation: a meta-analysis
- Systematic review and meta-analysis of observational studies
- prespecified protocol
Authors' conclusion
Screening family members of people with BAV can identify a cohort substantially enriched for the presence of bicuspid valve, aortic enlargement, or both.
Study context
- Population
- First-degree relatives of people with bicuspid aortic valve (BAV) screened for BAV and aortic dilatation
- Participants
- 6,054 relatives · 23 studies
- Outcome
- Screened prevalence of BAV and aortic dilatation among relatives
Pooled result
As reported in the abstract
Prevalence of BAV among relatives, overall
7.3% (95% CI 6.1%-8.6%)
Prevalence of BAV per family
23.6% (95% CI 18.1%-29.5%)
Prevalence of aortic dilatation among relatives
9.4% (95% CI 5.7%-13.9%)
Further pooled results
Aortic dilatation prevalence by relative's valve type (subgroup)
- Relatives with BAV
- 29.2% (95% CI 15.3%-45.1%)
- Relatives with tricuspid valves, higher than in the general population
- 7.0% (95% CI 3.2%-12.0%)
- Aortic dilatation with tricuspid valves more frequent overall, as many more relatives had tricuspid valves
Original publication
Family screening for bicuspid aortic valve and aortic dilatation: a meta-analysis. Eur Heart J. Published 8 June 2023. doi:10.1093/eurheartj/ehad320
Summarised from the published abstract; every number is checked against it