Valvular & structural heart disease
Recurrence of syncope after valve replacement in severe aortic stenosis
Authors' conclusion
Syncope on exertion in patients with SAS did not recur after aortic valve intervention. Syncope at rest recurs in a high proportion of patients and identifies a population with increased mortality.
Study context
- Population
- Patients with symptomatic severe AS without other valve disease and/or CAD who underwent valve intervention and were discharged alive53 with syncope
- Participants
- 320 patients
- Exposure
- Syncope on exertion vs syncope at rest before valve intervention
- Syncope on exertionn = 29
- Syncope at restn = 21
- Outcome
- Recurrence of syncope after valve replacement and its impact on mortality (all-cause and CV mortality)
- Follow-up
- Median 69 months (IQR: 55-88)
Methodological detailsdouble-centre, consecutive patients
- Double-centre
- Consecutive patients
Main finding
As reported in the abstract
Recurrence of syncope after valve intervention
| Group | Value | Recurrence |
|---|---|---|
| Syncope on exertion | did not recur in any patient | |
| Syncope at rest | 38% |
Value
Syncope on exertion— not stated in the abstract
Syncope at rest38%
Recurrence
Syncope on exertiondid not recur in any patient
Syncope at rest— not stated in the abstract
- Postintervention syncope at rest in patients with syncope at rest
- P < 0.001
Observational data: associations, not effects.
Further findings
CV mortality associated with recurrence of syncope
| HR (95% CI) | P value | ||
|---|---|---|---|
| Recurrence of syncopeOnly recurrence of syncope was associated with CV mortality | 5.74 (2.17–15.17) | P < 0.001 | |
| 0.050.21520Hazard ratio (log scale) |
Original publication
Recurrence of syncope after valve replacement in severe aortic stenosis. Heart. Published 7 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →