Arrhythmias & electrophysiology
Fascicular Substrate Modification to Treat Human Ventricular Fibrillation
Authors' conclusion
Catheter ablation of human VF and PMVT with FSM is feasible and safe and appears highly effective, with high rates of acute VF noninducibility and long-term freedom from recurrent VF.
Study context
- Population
- Patients with ventricular fibrillation (VF) or polymorphic ventricular tachycardia (PMVT) undergoing catheter ablation, ≥2 failed antiarrhythmic drugsof 2,212 ablation patients
- Participants
- 18 patients
- Exposure
- Idiopathic VF vs Underlying cardiomyopathy
- Idiopathic VFn = 11
- Underlying cardiomyopathyn = 7
- Outcome
- Arrhythmia free on or off drugs
- Follow-up
- Median 24 months
Methodological detailsconsecutive patients, prospectively collected institutional database
- Consecutive patients
- Prospectively collected institutional database
Main finding
As reported in the abstract
P = 0.06
- Overall arrhythmia free
- 16 patients (88.9%)
Observational data: associations, not effects.
Safety
- No procedure-related complications
- No new fascicular block or bundle branch block
Original publication
Fascicular Substrate Modification to Treat Human Ventricular Fibrillation. JACC Clin Electrophysiol. Published 12 June 2024. doi:10.
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