Association of vessel fractional flow reserve (vFFR) with luminal obstruction and plaque characteristics as detected by optical coherence tomography (OCT) in patients with NSTE-ACS: the FAST OCT study
Authors' conclusion
In patients with NSTE-ACS, vFFR is significantly associated with OCT-detected MLA, and vFFR ≤ 0.80 is highly predictive of the presence of significant disease based on OCT. Conversely, the sensitivity of vFFR ≤ 0.80 to detect OCT-assessed significant disease was low, indicating that the presence of significant OCT findings cannot be ruled out based on a negative vFFR.
Study context
- Population
- Patients with NSTE-ACS and intermediate to severe coronary stenosis with TIMI 3 flow suitable for OCT
- Participants
- 188 patients226 vessels
- Exposure
- vFFR vs OCT findings
- Outcome
- Association between vFFR and OCT findings in intermediate coronary lesions
Methodological detailsmulticenter, single-arm
- Multicenter
- Single-arm
Main finding
As reported in the abstract
Association of vFFR with OCT MLA
Average decrease in minimal lumen area (MLA) per 0.10 decrease in vFFR
20.4%
95% CI −23.9% to −16.7%adjusted P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| Detection of MLA ≤ 2.5 mm² | vFFR ≤ 0.80 Sensitivity 56.7% · Specificity 92.5% |
Detection of plaque instability
- vFFR sensitivity (poor to moderate discriminative ability)
- 46.9%
- vFFR specificity
- 71.6%
Original publication
Association of vessel fractional flow reserve (vFFR) with luminal obstruction and plaque characteristics as detected by optical coherence tomography (OCT) in patients with NSTE-ACS: the FAST OCT study. Eur Heart J Cardiovasc Imaging. Published 28 August 2024. doi:10.
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