FFR-Negative Nonculprit High-Risk Plaques and Clinical Outcomes in High-Risk Populations: An Individual Patient-Data Pooled Analysis From COMBINE (OCT-FFR) and PECTUS-obs
Authors' conclusion
FFR-negative but high-risk nonculprit lesions are associated with adverse patient- and lesion-level clinical outcomes. These findings emphasize the additional value of intracoronary imaging in patients with FFR-negative nonculprit lesions.
Study context
- Population
- Patients with diabetes or presenting with myocardial infarction with fractional flow reserve (FFR)-negative (FFR >0.80) native nonculprit lesions assessed by optical coherence tomography450 (55.6%) with history of diabetes, 482 (59.5%) presented with myocardial infarction
- Participants
- 810 patients
- Comparison
- Patients or lesions with a high-risk plaque were compared with those without a high-risk plaque.
- High-risk plaquen = 271 (33.5%) patients and 287 (30.6%) lesions
- Outcome
- Native major adverse cardiovascular events (patient-level) and target lesion failure (lesion-level)
- Follow-up
- Median 761 (interquartile range, 731-1175) days
Methodological detailsindividual patient-data
- Individual patient-data
Pooled result
As reported in the abstract
High-risk plaque vs without a high-risk plaqueHazard ratio (95% CI)P value
Patient-level native major adverse cardiovascular events
2.127(1.451–3.120)
P < 0.001Lesion-level target lesion failure
2.623(1.559–4.414)
P < 0.001Further pooled results
Risk of adverse outcomes by number of high-risk features
- The risk of adverse outcomes increased with the copresence of multiple high-risk features.
Original publication
FFR-Negative Nonculprit High-Risk Plaques and Clinical Outcomes in High-Risk Populations: An Individual Patient-Data Pooled Analysis From COMBINE (OCT-FFR) and PECTUS-obs. Circ Cardiovasc Interv. Published 22 January 2025. doi:10.
Summarised from the published abstract; every number is checked against it