Valvular & structural heart disease
Favorable Effects of Atrial Fixation Transcatheter Mitral Valve Replacement on Left Atrium Volume and Strain
Authors' conclusion
There was a presence of LA remodeling following AltaValve System implantation and this was accompanied by a reduction in LA strain for both the reservoir and conduit phases, without changes in contractility.
Study context
- Population
- Patients with severe, symptomatic mitral regurgitation undergoing AltaValve System transcatheter mitral valve replacement (TMVR)
- Participants
- 16 patients
- Exposure
- Baseline vs 6-month follow-up after AltaValve TMVR
- Transseptaln = 8
- Transapicaln = 8
- Outcome
- Anatomical and functional changes of the LA (LA volumes and strain by TTE)
- Follow-up
- 6-month follow-up
Methodological detailsSuccessful implantation in all patients
- Successful implantation in all patients
Main finding
As reported in the abstract
6 months
- Left atrium (LA) volume: 117.4 ± 39 mL vs 93.0 ± 37.0 mL
- P = 0.002
- LA reservoir strain: 10.8% ± 5.8% vs 1.6% ± 2.1%
- P < 0.001
- LA conduit strain: −9.7% ± 3.2% vs −4.2% ± 4.4%
- P = 0.013
- LA contraction strain, no significant change: −1.1% vs −2.7%
- P = 0.079
Observational data: associations, not effects.
Further findings
6-minute walk distance (13 patients) · 6 months
- Significant improvement, average 253 m at baseline to 296 m
Functional status · 6-month follow-up
- 55.1 ± 20.5 at baseline to 67.0 ± 22.5
- P = 0.04
Responders: LA parameters incl. strain · 6-month follow-up
- Statistically significant differences for majority of LA parameters including strain
Original publication
Favorable Effects of Atrial Fixation Transcatheter Mitral Valve Replacement on Left Atrium Volume and Strain. JACC Adv. Published 16 October 2025. doi:10.
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