Feasibility of Treat and Repair Strategy in Congenital Heart Defects With Pulmonary Arterial Hypertension
Authors' conclusion
In this small cohort, a treat and repair strategy was successfully used in a significant proportion of the patients with congenital heart defects with moderate to severe PAH.
Study context
- Population
- Patients with atrial or ventricular septal defect and pulmonary arterial hypertension (PAH) (PVR ≥ 5 Wood units) eligible for treat and repair strategy
- Participants
- 25 patients
- Exposure
- Repaired vs unrepaired after treat and repair strategy
- Repairedn = 20
- Unrepairedn = 5reference
- Outcome
- Pretreatment variables associated with successful defect repair
Main finding
As reported in the abstract
Pretreatment variables associated with defect repair
- Pretreatment mean pulmonary artery pressure, PVR, Qp/Qs and arterial oxygen saturations associated with undergoing defect repair
Observational data: associations, not effects.
Further findings
PVR, repaired group (pretreatment vs pre-repair) · significant decrease
ß coefficient −4.6 (−5.9 to −3.3)
| Outcome | Pretreatment | Pre-repair | ß coefficient (95% CI) |
|---|---|---|---|
| Qp/Qs, repaired group (pretreatment vs pre-repair) | 1.5 ± 0.6 | 2.4 ± 1.3 | 0.9 (0.4–1.38) |
PVR and Qp/Qs, unrepaired group
- PVR decreased with treatment but remained elevated
- Qp/Qs did not change between pretreatment and post-treatment
Pretreatment variables associated with defect repair
- Pretreatment mean pulmonary artery pressure, PVR, Qp/Qs and arterial oxygen saturations associated with undergoing defect repair
Original publication
Feasibility of Treat and Repair Strategy in Congenital Heart Defects With Pulmonary Arterial Hypertension. JACC Adv. Published 6 March 2024. doi:10.
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