Arrhythmias & electrophysiology
Feasibility study on atrial fibrillation ablation with pulsed field ablation and concomitant occlusion of the left atrial appendage
Authors' conclusion
Simultaneous PFA-based AF ablation and LAAO in carefully selected patients is feasible and safe and can be executed within a short overall procedure duration.
Study context
- Population
- Patients qualifying for both atrial fibrillation (AF) ablation and left atrial appendage occlusion (LAAO), excluding complex anatomy2 excluded (complex LAA anatomy)
- Participants
- 10 / 207 / 61
- Comparison
- Combined pulsed field ablation (PFA)-based AF ablation plus LAAO vs individual AF ablation or LAAO alone
- Combined proceduren = 10
- AF ablationn = 207reference
- LAAOn = 61reference
- Outcome
- Procedure duration and fluoroscopy time
Methodological detailssame operators, comparison with individual procedures
- Same operators
- Comparison with individual procedures
Main finding
As reported in the abstract
Total procedure duration
| Group | Value | Fluoroscopy time | Without 3-dimensional electroanatomic mapping | With 3-dimensional electroanatomic mapping |
|---|---|---|---|---|
| Combined procedure | median 79 (range 60–125) min | 21 (15-26) min | ||
| AF ablation | median 71 (range 25–241) min | 15 (5-44) min | 51 min | 78 min |
| LAAO | median 47 (range 15–162) min | 10 (3-50) min |
Value
Combined proceduremedian 79 (range 60–125) min
AF ablationmedian 71 (range 25–241) min
LAAOmedian 47 (range 15–162) min
Fluoroscopy time
Combined procedure21 (15-26) min
AF ablation15 (5-44) min
LAAO10 (3-50) min
Without 3-dimensional electroanatomic mapping
Combined procedureNot reported in the abstract
AF ablation51 min
LAAONot reported in the abstract
With 3-dimensional electroanatomic mapping
Combined procedureNot reported in the abstract
AF ablation78 min
LAAONot reported in the abstract
Further findings
Components of the combined procedure duration
min
- Femoral vein access to last PFA application
- 49 (34-93)
- Time added by LAAO
- 20 (15-37)
Individual AF ablation procedure duration, by 3-dimensional electroanatomic mapping
min
- Without 3-dimensional electroanatomic mapping
- 51
- With 3-dimensional electroanatomic mapping
- 78
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Feasibility study on atrial fibrillation ablation with pulsed field ablation and concomitant occlusion of the left atrial appendage. Europace. Published 25 June 2024. doi:10.
Summarised from the published abstract; every number is checked against it