Arrhythmias & electrophysiologyCohort study
Female sex as an independent predictor of major complications during transvenous lead extraction
- retrospective analysis
- 3 high-volume centers
- 1 primary operator
- propensity score matched 1:1
Authors' conclusion
After extensive balancing of confounders, female sex remained independently associated with major complications during TLE, supporting further investigation of sex-related procedural vulnerability and refinement of TLE risk models.
Study context
- Population
- Patients undergoing nonlaser transvenous lead extraction (TLE) (2006–2024)matched cohort: 1197 women and 1197 men
- Participants
- 4,290 patients
- Exposure
- Women vs men, matched 1:1 on 10 clinical and procedural covariates
- Womenn = 1,197
- Menn = 1,197
- Outcome
- Major complications (Heart Rhythm Society/European Heart Rhythm Association criteria)
Main finding
As reported in the abstract
P < 0.001
Observational data: associations, not effects.
Further findings
Hemopericardium
P = 0.001
Rescue cardiac surgery
P = 0.006
Major complications, multivariable logistic regression
| Comparison | OR (95% CI) | P value | |
|---|---|---|---|
| Female sex · independently associated | 2.72 (1.52–4.85) | P < 0.001 | |
| 0.20.5125Odds ratio (log scale) |
| Outcome | Estimate | P value | |
|---|---|---|---|
| Major complications, multivariable logistic regression — Lead dwell time · longer dwell time | OR 1.12 per year (95% CI 1.07–1.17) | P < 0.001 | |
| Major complications, multivariable logistic regression — Hemoglobin concentration · higher hemoglobin associated with lower odds | OR 0.86 per 1 g/dL (95% CI 0.76–0.98) | P = 0.026 | |
| 0.512Odds ratio (log scale) |
Procedural success
- procedural success was similar
Original publication
Female sex as an independent predictor of major complications during transvenous lead extraction. Heart Rhythm. Published 4 September 2026. doi:10.1016/j.hrthm.2026.08.049
Summarised from the published abstract; every number is checked against it