Arrhythmias & electrophysiologyResearch article
Female Sex Is Not a Uniform Risk Factor in Atrial Fibrillation
- propensity matched analysis using TriNetX
- propensity matched for comorbidities and anticoagulation
- 1-year follow-up
Authors' conclusion
Female sex acts as a modest risk modifier for thromboembolic stroke. Increased risk is primarily observed in patients with greater comorbidity burden or advanced age (≥75 years).
Study context
- Population
- Nonvalvular atrial fibrillation (AF) patients stratified by sex and age (<65, 65–74, and ≥75 years)without additional CHA2DS2-VA risk factors or anticoagulation 252,528 · with one additional CHA2DS2-VA risk factor 607,612
- Comparison
- comparing male and female patients with no CHA2DS2-VA risk factors beyond age and with one additional CHA2DS2-VA risk factor
Main finding
As reported in the abstract
Stroke, patients without additional CHA2DS2-VA risk factors or anticoagulation · 1-year follow-up
Hazard ratio
1.244
95% CI 1.087–1.423
P = 0.001
Female vs Male
HR 1.244 (95% CI 1.087–1.423); P = 0.001
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Stroke, patients with one additional CHA2DS2-VA risk factor · 1-year follow-up · female patients ≥75 years | 1.065 (1.014–1.118) | P = 0.012 | |
| 0.512Hazard ratio (log scale) |
Original publication
Female Sex Is Not a Uniform Risk Factor in Atrial Fibrillation. JACC Adv. Published 3 June 2026. doi:10.1016/j.jacadv.2026.102826
Summarised from the published abstract; every number is checked against it