Arrhythmias & electrophysiology
Fetal Bradycardia Prompting the Diagnosis and Management of Parental Long QT Syndrome
Authors' conclusion
The first indication of parental LQTS may be persistent fetal bradycardia.
Study context
- Population
- Parents of fetuses with persistent bradycardia and suspected congenital long QT syndrome (excluding autoimmune-mediated AV block and fetal VT)20 mothers
- Outcome
- Pathogenic LQTS genetic variants in fetuses and parents
Methodological detailsJanuary 1, 2018 to November 1, 2023, Comprehensive evaluation incl. genomic testing in 12 mothers and 11 fathers
- January 1, 2018 to November 1, 2023
- Comprehensive evaluation incl. genomic testing in 12 mothers and 11 fathers
Main finding
As reported in the abstract
Fetuses with pathogenic Long QT syndrome (LQTS) variants (KCNQ1=8; KCNE1=1; KCNH2=1; CALM2=1)
11
Mothers with pathogenic LQTS variants (KCNQ1=7; KCNE1=1; KCNH2=1)
9
Observational data: associations, not effects.
Further findings
Maternal corrected QT interval, pathogenic variant vs no genomic testing
P = 0.009
- Maternal corrected QT interval, pathogenic variant vs no genomic testing — Corrected QT interval in paternal carrier
- <400 ms
Management
- Mothers with pathogenic variants commenced on β-blockers (prepartum=4; postpartum=1)
- 5
- β-blockade initiated postnatally after treadmill exercise provocation testing
- 1
Original publication
Fetal Bradycardia Prompting the Diagnosis and Management of Parental Long QT Syndrome. Circ Arrhythm Electrophysiol. Published 2 December 2025. doi:10.
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