First-In-Human Study of [ 64 Cu]Cu-DOTATATE PET/CT in Infective Endocarditis: A Prospective Head-to-Head Comparison With [ 18 F]FDG
Authors' conclusion
[ 64 Cu]Cu-DOTATATE PET/CT showed uptake in the infected valve in patients with IE, and has major advantage as it does not require any preparation compared with [ 18 F]FDG. [ 64 Cu]Cu-DOTATATE had a numerically higher specificity than [ 18 F]FDG, although the difference was not statistically significant. Both tracers were limited in the detection of native valve endocarditis.
Study context
- Population
- Patients with infective endocarditis (prosthetic valve and native valve endocarditis) and controls20 patients with infective endocarditis (IE) and 20 controls
- Exposure
- [ 64 Cu]Cu-DOTATATE vs [ 18 F]FDG PET/CT tracer uptake, sensitivity and specificity in patients with IE and controls
- IEn = 20
- Prosthetic valve endocarditisn = 10
- Native valve endocarditisn = 10
- Controlsn = 20
- Outcome
- Age
Methodological detailsfirst-in-human, head-to-head comparison, scans read blinded to clinical data
- First-in-human
- Head-to-head comparison
- Scans read blinded to clinical data
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Values | P value |
|---|---|---|
| [ 64 Cu]Cu-DOTATATE uptake (median maximum standardized uptake value [IQR])IE vs controls · higher in patients with IE · Wilcoxon rank tests | IE median 2.34 (IQR 1.40–3.23) · controls median 1.44 (IQR 1.21–1.60) · prosthetic valve endocarditis median 3.23 (IQR 2.02–3.86) · native valve endocarditis median 1.51 (IQR 1.23–2.58) | P = 0.008 |
| [ 64 Cu]Cu-DOTATATE uptake (median maximum standardized uptake value [IQR])Prosthetic valve endocarditis vs controls · Wilcoxon rank tests | P < 0.001 | |
| [ 64 Cu]Cu-DOTATATE uptake (median maximum standardized uptake value [IQR])Native valve endocarditis vs controls · Wilcoxon rank tests | P = 0.428 | |
| Sensitivity and specificity, 20 cases versus 20 controls | [ 64 Cu]Cu-DOTATATE PET/CT specificity 90% · [ 18 F]FDG PET/CT specificity 75% | |
| Sensitivity and specificity, prosthetic valve endocarditis versus the 20 controls | [ 64 Cu]Cu-DOTATATE PET/CT sensitivity 80% · specificity 90% · [ 18 F]FDG PET/CT sensitivity 80% · specificity 75% | P = 0.38 |
Sensitivity and specificity, 20 cases versus 20 controls
- Sensitivity equal
Proportion of scans achieving diagnostic certainty
- Greater with [ 64 Cu]Cu-DOTATATE PET/CT than [ 18 F]FDG PET/CT for native valve endocarditis, prosthetic valve endocarditis, and controls
Original publication
First-In-Human Study of [ 64 Cu]Cu-DOTATATE PET/CT in Infective Endocarditis: A Prospective Head-to-Head Comparison With [ 18 F]FDG. Circ Cardiovasc Imaging. Published 4 February 2025. doi:10.
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