Heart failure & cardiomyopathies
First Report of the Clinical Characteristics and Outcomes of Cardiac Amyloidosis in Saudi Arabia
Authors' conclusion
The prevalence of CA among screened heart failure patients here aligns with major international studies, suggesting significant underdiagnosis in the region.
Study context
- Population
- HF patients with red flags for cardiac amyloidosis (CA) who underwent CA screening, tertiary hospital in Riyadh, Saudi Arabia, August 2018–July 2022screened
- Participants
- 177 patients
- Exposure
- Positive vs negative/equivocal [99mTc]Tc-PYP scans; ATTR-CA and AL-CA vs other HF aetiologies
- Outcome
- Prevalence of CA
Methodological detailsretrospective, single-centre
- Retrospective
- Single-centre
Main finding
As reported in the abstract
ATTR-CA
21.0
11.9%
AL-CA
13
7.3%
Observational data: associations, not effects.
Further findings
Age, positive vs negative/equivocal PYP
P < 0.001
Biomarkers, imaging and ECG, positive vs negative/equivocal PYP
- Higher troponin
- P = 0.003
- Higher N-terminal pro-brain natriuretic peptide (NT-proBNP)
- P < 0.001
- Higher left ventricular (LV) mass index
- P < 0.001
- More depressed global longitudinal strain (GLS)
- P < 0.001
- Greater prevalence of relative apical sparing pattern
- P < 0.001
- Higher incidence of first-degree AV block
- P = 0.008
- Low voltage on ECG
- P < 0.001
ATTR-CA and AL-CA vs other HF aetiologies
- More likely subendocardial or transmural late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR)
- P < 0.001
- Significantly lower overall survival
- P < 0.001
Original publication
First Report of the Clinical Characteristics and Outcomes of Cardiac Amyloidosis in Saudi Arabia. ESC Heart Fail. Published 1 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →