Heart failure & cardiomyopathies
Prevalence of Transthyretin Amyloidosis Among Heart Failure Patients with Preserved Ejection Fraction in Japan
Authors' conclusion
ATTR-CM is an underdiagnosed disease with a significant prevalence in Japanese patients with HFpEF.
Study context
- Population
- Patients with heart failure with preserved ejection fraction (HFpEF) (LVEF ≥50%) aged ≥65 years admitted to cardiology, Japan, September 2018 to January 2022
- Participants
- 373 patients
- Exposure
- ATTR-CM vs non-ATTR-CM
- ATTR-CMn = 53
- non-ATTR-CMn = 320reference
- Outcome
- Prevalence of ATTR-CM (positive 99mTc-PYP scintigraphy)
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Prevalence of ATTR-CM
ATTR-CM
14.2%
53
Observational data: associations, not effects.
Further findings
| Outcome | ATTR-CM | non-ATTR-CM | P value |
|---|---|---|---|
| NT-proBNP | 2314 (range as printed 1081–3398) | 900 (range as printed 415–1828) | P < 0.001 |
| Sensitive troponin T | 0.074 ± 0.049 | 0.035 ± 0.038 | P < 0.001 |
| Mean LV maximal wall thickness | 12.5 (range as printed 11–14) | 10.5 (range as printed 9.5–11.5) | P < 0.001 |
Age, New York Heart Association (NYHA) class, renal function, LVEF, tricuspid regurgitant pressure gradient
- No significant differences between the two groups
Original publication
Prevalence of Transthyretin Amyloidosis Among Heart Failure Patients with Preserved Ejection Fraction in Japan. ESC Heart Fail. Published 27 March 2023. doi:10.
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