Valvular & structural heart disease
Five-Year Clinical Outcomes and Durability of a Self-Expanding Transcatheter Heart Valve With Intra-Annular Leaflets
Authors' conclusion
Furthermore, bioprosthetic valve failure rates were low with no incidence of severe hemodynamic structural valve deterioration at 5 years, irrespective of annular size.
Study context
- Population
- Severe symptomatic AS at high or extreme surgical risk
- Participants
- 1,464 participants3 studies
- Outcome
- Clinical outcomes and valve durability
- Follow-up
- 5 years
Methodological detailsrandom-effects meta-analysis model, independent core laboratory echocardiographic analysis, independent clinical events committee adjudication
- Random-effects meta-analysis model
- Independent core laboratory echocardiographic analysis
- Independent clinical events committee adjudication
Main finding
As reported in the abstract
- All-cause mortality
- 49.4%
- Stroke
- 12.3%
- Transvalvular gradient
- 6.2 mm Hg
- Effective orifice area
- 1.83 cm²
- Paravalvular leak ≥moderate
- 1.9%
- Bioprosthetic valve failure
- 2.7%
- Valve-related death
- 0.7%
- Valve reintervention
- 2.0%
- Severe hemodynamic structural valve deterioration
- 0
- Moderate hemodynamic structural valve deterioration
- 0.9%
Observational data: associations, not effects.
Further findings
Hemodynamics and durability by annular size
- Remained stable irrespective of annular size
Original publication
Five-Year Clinical Outcomes and Durability of a Self-Expanding Transcatheter Heart Valve With Intra-Annular Leaflets. Circ Cardiovasc Interv. Published 24 October 2025. doi:10.
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