Valvular & structural heart disease
Impact of Triglycerides and Remnant Particles on Hemodynamic Valve Deterioration After Transcatheter Aortic Valve Replacement
Authors' conclusion
Elevated triglycerides and remnant cholesterol were associated with a higher cumulative incidence of HVD, and elevated triglycerides were associated with a higher annualized rate of change in peak aortic jet velocity.
Study context
- Population
- Patients who underwent transcatheter aortic valve replacement (TAVR) with echocardiographic follow-up, UC San Diego Health STS/ACC TVT registry, May 2013 to December 2022
- Participants
- 555 patients
- Exposure
- Cardiometabolic factors and hemodynamic valve deterioration (HVD) after TAVR
- Outcome
- Moderate or severe HVD (VARC-3), all-cause death as competing risk
Methodological detailssingle-centre registry
- Single-centre registry
Main finding
As reported in the abstract
Moderate or severe HVD · median 3.7 years
Hazard ratio (95% CI)P value
Elevated triglycerides (>100 mg/dL)
3.81(1.75–8.29)
P < 0.001Remnant cholesterol
1.03(1.02–1.04)
P < 0.001- HVD incidence (all patients)
- 6.3%
Observational data: associations, not effects.
Further findings
M/s/y
| Outcome | Elevated triglycerides | Not elevated triglycerides | P value |
|---|---|---|---|
| Annualized rate of change in peak aortic jet velocity | 0.01 (IQR −0.07–0.18) | −0.02 (IQR −0.13–0.09) | P = 0.027 |
Original publication
Impact of Triglycerides and Remnant Particles on Hemodynamic Valve Deterioration After Transcatheter Aortic Valve Replacement. JACC Adv. Published 21 October 2025. doi:10.
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