Five-Year Outcomes after Off-Pump or On-Pump Coronary-Artery Bypass Grafting
Primary resultResult — go to the resultHazard ratio 0.98 95% CI 0.87–1.10Authors' conclusion
In our trial, the rate of the composite outcome of death, stroke, myocardial infarction, renal failure, or repeat revascularization at 5 years of follow-up was similar among patients who underwent off-pump CABG and those who underwent on-pump CABG.
Study context
- Population
- Patients with CAD undergoing coronary-artery bypass grafting (CABG)
- Participants
- 4,752 patients
- Comparison
- Off-pump vs on-pump CABG
- Primary endpoint
- Composite of:
- Death
- Stroke
- MI
- Renal failure
- Repeat coronary revascularization (CABG or PCI)
- Follow-up
- 5 years (mean 4.8 years)
Methodological detailsmulticentre (19 countries)
- Multicentre (19 countries)
Primary result
As reported in the abstract
Hazard ratio
0.98
95% CI 0.87–1.10
P = 0.72
By group
Off-pump vs On-pump
HR 0.98 (95% CI 0.87–1.10); P = 0.72
Secondary outcomes
| Outcome | Off-pump | On-pump | HR (95% CI) | P value | |
|---|---|---|---|---|---|
| Repeat coronary revascularization | 2.8% | 2.3% | 1.21 (0.85–1.73) | P = 0.29 | |
| 0.512Hazard ratio (log scale) |
Mean $, U.S. dollars
| Outcome | Off-pump | On-pump | Between-group difference (U.S. dollars) (95% CI) |
|---|---|---|---|
| Mean cost per patient (overall trial period) | 15,107 | 14,992 | $115 (-$697 to $927) |
Other components of the composite outcome
- No significant differences in the rates of the components of the outcome
Quality of life
- No significant between-group differences in quality-of-life measures
Original publication
Five-Year Outcomes after Off-Pump or On-Pump Coronary-Artery Bypass Grafting. N Engl J Med. Published 23 October 2016. doi:10.
Summarised from the published abstract; every number is checked against it